Sensor Yatsopano Yovala Imazindikira Gout ndi Matenda Ena

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Gulu la ofufuza a Cal Tech motsogozedwa ndi Wei Gao, pulofesa wa biomedical engineering, adapanga sensa yovala yomwe imayang'anira kuchuluka kwa metabolites ndi michere m'magazi amunthu posanthula thukuta lawo.Zomverera zam'mbuyomu za thukuta nthawi zambiri zimayang'ana pazinthu zomwe zimawonekera kwambiri, monga ma electrolyte, glucose, ndi lactate.Chatsopanochi chimakhala chokhudzidwa kwambiri ndipo chimazindikira machulukidwe a thukuta pamunsi kwambiri.Ndiwosavuta kupanga ndipo imatha kupangidwa mochuluka.

Cholinga cha gululi ndi sensa yomwe imalola madokotala kupitiriza kuyang'anira odwala omwe ali ndi matenda monga matenda a mtima, matenda a shuga, ndi matenda a impso, zonse zomwe zimayika zakudya zopanda thanzi kapena metabolites m'magazi.Odwala akanakhala bwino ngati dokotala wawo akudziwa zambiri za matenda awo ndipo njira imeneyi imapewa kuyezetsa komwe kumafuna singano ndi kuyesa magazi.

“Masensa ovala thukuta otere amatha kujambula mwachangu, mosalekeza, komanso mosasokoneza kusintha kwaumoyo pamlingo wamagulu,†akutero Gao.“Atha kupangitsa kuti kuwunika kwamunthu payekha, kuzindikira matenda msanga, ndi kuchitapo kanthu pa nthawi yake kutheke.â

Sensa imadalira microfluidics yomwe imagwiritsa ntchito zakumwa zochepa, nthawi zambiri kudzera mumayendedwe osakwana kotala la millimeter m'lifupi.Ma Microfluidics ndi oyenera kugwiritsa ntchito chifukwa amachepetsa kutulutsa thukuta komanso kuipitsidwa kwa khungu pakulondola kwa sensor.Pamene thukuta lomwe langoperekedwa kumene limayenda kudzera m'masensa aang'ono, limayesa bwino momwe thukuta limapangidwira ndikusintha kusintha kwa nthawi.

Mpaka pano, Gao ndi anzake akuti, masensa opangidwa ndi microfluidic opangidwa ndi microfluidic amapangidwa makamaka ndi njira ya lithography-evaporation, yomwe imafuna njira zopangira zovuta komanso zodula.Gulu lake lidasankha kupanga ma biosensors ake kuchokera ku graphene, mawonekedwe ngati pepala la kaboni.Masensa onse opangidwa ndi graphene ndi ma microfluidics amapangidwa polemba mapepala apulasitiki ndi laser carbon dioxide, chipangizo chodziwika bwino chomwe chimapezeka kwa okonda kunyumba.

Gulu lofufuza lidapanga sensa yake kuti iyesenso kupuma ndi kugunda kwa mtima, kuwonjezera pa milingo ya uric acid ndi tyrosine.Tyrosine anasankhidwa chifukwa akhoza kukhala chizindikiro cha matenda kagayidwe kachakudya, matenda chiwindi, matenda kudya, ndi matenda neuropsychiatric.Uric acid idasankhidwa chifukwa, pamilingo yokwera, imalumikizidwa ndi gout, matenda opweteka omwe akukula padziko lonse lapansi.Gout imachitika pamene kuchuluka kwa uric acid m'thupi kumayamba kunyezimira m'malo olumikizirana mafupa, makamaka m'mapazi, zomwe zimayambitsa kutupa ndi kutupa.

Kuti awone momwe masensawo adayendera bwino, ofufuza adayesa pa anthu athanzi komanso odwala.Kuti aone kuchuluka kwa thukuta la tyrosine lomwe limatengera kulimba kwa thupi la munthu, adagwiritsa ntchito magulu awiri a anthu: othamanga ophunzitsidwa bwino komanso anthu olimba kwambiri.Monga zikuyembekezeredwa, masensawo adawonetsa kuchepa kwa tyrosine mu thukuta la othamanga.Kuti aone kuchuluka kwa uric acid, ochita kafukufukuwo adayang'anitsitsa thukuta la gulu la anthu athanzi lomwe linali kusala kudya, komanso pambuyo poti ophunzirawo adya chakudya chokhala ndi purines - mankhwala omwe amapezeka muzakudya zomwe zimasinthidwa kukhala uric acid.Sensa idawonetsa kuchuluka kwa uric acid kukwera pambuyo pa chakudya.Gulu la Gao linayesanso chimodzimodzi ndi odwala gout.Sensayo inawonetsa kuti milingo yawo ya uric acid inali yokwera kwambiri kuposa ya anthu athanzi.

Kuti awone kulondola kwa masensawo, ochita kafukufukuwo adajambula ndikuyang'ana zitsanzo za magazi kuchokera kwa odwala gout ndi maphunziro athanzi.Miyezo ya masensa ya uric acid imagwirizana kwambiri ndi milingo yake m'magazi awo.

Gao akuti kukhudzika kwakukulu kwa masensawo, komanso kumasuka komwe angapangire, kumatanthauza kuti pamapeto pake atha kugwiritsidwa ntchito ndi odwala kunyumba kuti aziwunika zinthu monga gout, shuga, komanso matenda amtima.Kukhala ndi chidziwitso cholondola chokhudza thanzi lawo kumatha kulola odwala kuti asinthe mlingo wawo wamankhwala ndi zakudya momwe angafunikire.