Esi siza siqhutywa lishishini okanye amashishini aphethwe yi-Informa PLC kwaye onke amalungelo okukopisha ahlala kuwo.Iofisi ebhalisiweyo ye-Informa PLC iku-5 Howick Place, eLondon SW1P 1WG.Ibhaliswe eNgilani naseWales.Inombolo 8860726.
Iqela lomphandi weCal Tech elikhokelwa ngu-Wei Gao, unjingalwazi wezobunjineli bebhayoloji, uphuhlise inzwa yokunxiba ebeka iliso kumanqanaba e-metabolites kunye nezondlo egazini lomntu ngokuhlalutya ukubila kwabo.Izinzwa zombilo zangaphambili bezijolise ikakhulu kwiikhompawundi ezibonakala kuxinzelelo oluphezulu, njenge-electrolytes, iswekile, kunye nelactate.Eli litsha linobuntununtunu kwaye libhaqa iikhompawundi zokubila kwindawo ezisezantsi kakhulu.Ikwalula ukuyivelisa kwaye inokuveliswa ngobuninzi.
Injongo yeqela yinzwa evumela oogqirha ukuba baqhubeke bebeka iliso kwimeko yezigulane ezinezifo ezifana nesifo senhliziyo, isifo seswekile, kunye nesifo sezintso, zonke ezibeka amanqanaba angaqhelekanga ezondlo okanye i-metabolites egazini.Izigulana zingaphila ngcono ukuba ugqirha wazo uyazi ngakumbi ngeemeko zabo zobuqu kwaye le ndlela ithintela uvavanyo olufuna iinaliti kunye nesampula yegazi.
"Ezi zinzwa zokubila ezinxitywayo zinokukhawuleza, ngokuqhubekayo, kwaye zibambe utshintsho kwimpilo kumanqanaba eemolekyuli," utshilo uGao.“Banokwenza ujongo olulolwakho, ukuxilonga kwangethuba, kunye nongenelelo olungexesha olunokwenzeka.â
Isivamvo sixhomekeke kwi-microfluidics elawula amanani amancinci olwelo, ngokuqhelekileyo ngeeshaneli ezingaphantsi kwekota ye-millimeter ububanzi.I-Microfluidics ifaneleke kakuhle kwisicelo kuba inciphisa impembelelo yokunyuka kombilo kunye nokungcoliseka kwesikhumba ekuchanekeni kwenzwa.Njengoko ukubila okusandula kunikezelwa kutyhutyha kwi-microchannels ye-sensor, ilinganisa ngokuchanekileyo ukubunjwa kombilo kwaye ibambe utshintsho ekugxininiseni ixesha.
Ukuza kuthi ga ngoku, uGao kunye noogxa bakhe bathi, izinzwa ezinxitywayo ezisekwe kwi-microfluidic ubukhulu becala zenziwe nge-lithography-evaporation approach, efuna iinkqubo ezintsonkothileyo nezixabisayo.Iqela lakhe likhethe ukwenza ii-biosensors zayo ngegraphene, uhlobo olufana nephepha lekhabhoni.Zombini i-graphene-based sensors kunye ne-microfluidics channels zenziwe ngokukrola amaphepha eplastiki nge-carbon dioxide laser, isixhobo esixhaphake kakhulu ukuba sifumaneke kwii-hobbyists zasekhaya.
Iqela lophando lenze inzwa yalo ukuba ilinganise izinga lokuphefumula kunye nentliziyo, ngaphezu kwamanqanaba e-uric acid kunye ne-tyrosine.I-Tyrosine ikhethwe ngenxa yokuba ingaba ngumqondiso wokuphazamiseka kwe-metabolic, isifo sesibindi, ukuphazamiseka kokutya, kunye neemeko ze-neuropsychiatric.I-Uric acid yakhethwa ngenxa yokuba, kumanqanaba aphakamileyo, inxulunyaniswa ne-gout, imeko ebuhlungu yamalungu eyanda kwihlabathi jikelele.Igawuthi yenzeka xa amanqanaba aphezulu euric acid emzimbeni eqala ukuqaqamba kumalungu, ngakumbi lawo eenyawo, nto leyo ebangela ukucaphuka nokudumba.
Ukubona ukuba abenzi boluvo basebenze kakuhle kangakanani na, abaphandi bayivavanya kubantu abasempilweni nakwizigulana.Ukujonga amanqanaba esweat tyrosine aphenjelelwa kukuqina komzimba womntu, basebenzise amaqela amabini abantu: iimbaleki eziqeqeshiweyo kunye nabantu abakwi-avareji yokuqina komzimba.Njengoko bekulindelekile, abenzi boluvo babonise amanqanaba asezantsi etyrosine kumbilo wabadlali.Ukujonga amanqanaba e-uric acid, abaphandi bajonge ukubila kweqela labantu abasempilweni ababezila ukutya, kwaye nasemva kokuba abafundi betyile ukutya okutyebileyo kwii-purines-iikhompawundi ekutyeni okwenziwa i-uric acid.Inzwa yabonisa amanqanaba e-uric acid enyuka emva kokutya.Iqela likaGao lenze uvavanyo olufanayo kwizigulana zegawuthi.Inzwa yabonisa amanqanaba abo e-uric acid aphezulu kakhulu kunabantu abasempilweni.
Ukujonga ukuchaneka kweenzwa, abaphandi badonsa kwaye bajonga iisampuli zegazi kwizigulane ze-gout kunye nezifundo eziphilileyo.Imilinganiselo yezinzwa zamanqanaba e-uric acid anxulunyaniswa ngamandla namanqanaba ayo egazini labo.
UGao uthi uvakalelo oluphezulu lwezinzwa, kunye nokulula enokwenziwa ngazo, kuthetha ukuba ekugqibeleni banokusetyenziswa zizigulana ekhaya ukujonga iimeko ezinje ngegout, isifo seswekile, kunye nezifo zentliziyo.Ukuba nolwazi oluchanekileyo lwexesha lokwenyani malunga nempilo yabo kunokuvumela izigulana zihlengahlengise amanqanaba amayeza kunye nokutya njengoko kufuneka.
Ixesha lokuposa: Dec-12-2019